Will seek out sunny locations and water. The fruit will become heavy enough to damage the climbing vine if it is not supported by nylon ties, trellising or cages. Will attract sugar ants, Japanese beetles and your normal squash bugs. I have yet to see significant damage done by any pests to these plants.
Tender vines should be handled with care when training. Protect it from frost like any squash. Can be sprouted indoors and transplanted outside after all danger of frost is past. Germinates in less than a week, should be transplanted as soon as cotyledons are free of the Testa(seed coat) and no later than emergence of first true leaves. Transplanting too late may result in stunted growth or plant death due to damaged root system.
Spaghetti Squash, like most squash, have very shallow root systems that are easy to damage during transplanting or cultivation around the plant. However, weeding is not a big concern around these plants as they tend to shade out anything growing in their path.
Harvest is typically 100 days from transplant to mature fruit.